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Article

NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives.

Gastroenterology - 1 Feb 2007

Devlin Shane M, Yang Huiying, Ippoliti Andrew, Taylor Kent D, Landers Carol J, Su Xiaowen, Abreu Maria T, Papadakis Konstantinos A, Vasiliauskas Eric A, Melmed Gil Y, Fleshner Phillip R, Mei Ling, Rotter Jerome I, Targan Stephan R

Abstract excerpt

BACKGROUND & AIMS: The Cdcs1 locus of the C3Bir mouse confers severe colitis associated with a decrease in innate immune function and an increase in adaptive T-cell responses to commensal bacterial products. The aim of our study was to determine if defects in innate immunity are similarly associated with increased adaptive immune responses to microbial antigens in Crohn's disease patients. METHODS: Sera from 732...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17258734
DOI: 10.1053/j.gastro.2006.11.013

Genes

NOD2
TLR4
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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