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Article

Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease.

Inflammatory bowel diseases - 1 Sept 2012

Murdoch Travis B, Xu Wei, Stempak Joanne M, Landers Carol, Targan Stephan R, Rotter Jerome I, Silverberg Mark S

Abstract excerpt

BACKGROUND: We sought to investigate whether variants in genes involved in bacterial sensing and autophagy (NOD2, TLR5, IRGM, ATG16L1) and the interleukin-23 signaling pathway (IL12B, IL23R, STAT3) were associated with development of antimicrobial antibodies in patients with Crohn's disease (CD). METHODS: A cohort of 616 CD patients from a tertiary referral hospital (Mount Sinai Hospital, Toronto) was evaluated....

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Source

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Identifiers

PMID: 22275320
DOI: 10.1002/ibd.22884
PMCID: PMC3418471

Genes

NOD2
IRGM
STAT3
TLR5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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