Article
Genetic and serological markers to identify phenotypic subgroups in a Dutch Crohn' s disease population.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Jan 2004
Linskens R K, Mallant-Hent R C, Murillo L S, von Blomberg B M E, Alizadeh B Z, Peña A S
Abstract excerpt
BACKGROUND AND AIMS: Both genetic and microbial factors seem to play a pivotal role in the aetiopathogenesis of Crohn's disease. The CARD15 frameshift mutation might link host genetic factors and the indigenous microbial flora, since CARD15 expression is stimulated by peptidoglycan, thereby activating NF-kappaB. It is hypothesised that CARD15 mutation carriers have defective anti-microbial reactions, resulting in...
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