Increased immune reactivity predicts aggressive complicating Crohn's disease in children.

doi:10.1016/j.cgh.2008.04.032

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Article

Increased immune reactivity predicts aggressive complicating Crohn's disease in children.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Oct 2008

Dubinsky Marla C, Kugathasan Subra, Mei Ling, Picornell Yoana, Nebel Justin, Wrobel Iwona, Quiros Antonio, Silber Gary, Wahbeh Ghassan, Katzir Lirona, Vasiliauskas Eric, Bahar Ron, Otley Anthony, Mack David, Evans Jonathan, Rosh Joel, Hemker Maria Oliva, Leleiko Neal, Crandall Wallace, Langton Christine, Landers Carol, Taylor Kent D, Targan Stephan R, Rotter Jerome I, Markowitz James, Hyams Jeffrey

Abstract excerpt

BACKGROUND & AIMS: The ability to identify children with CD who are at highest risk for rapid progression from uncomplicated to complicated phenotypes would be invaluable in guiding initial therapy. The aims of this study were to determine whether immune responses and/or CARD15 variants are associated with complicated disease phenotypes and predict disease progression. METHODS: Sera were collected from 796...

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Identifiers

PMID: 18619921
DOI: 10.1016/j.cgh.2008.04.032
PMCID: PMC3745777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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