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Article

Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum.

PloS one - 1 Jan 2013

Pfeiffer Verena, Götz Rudolf, Xiang Chaomei, Camarero Guadelupe, Braun Attila, Zhang Yina, Blum Robert, Heinsen Helmut, Nieswandt Bernhard, Rapp Ulf R

Abstract excerpt

This study focuses on the role of the kinase BRaf in postnatal brain development. Mice expressing truncated, non-functional BRaf in neural stem cell-derived brain tissue demonstrate alterations in the cerebellum, with decreased sizes and fuzzy borders of the glomeruli in the granule cell layer. In addition we observed reduced numbers and misplaced ectopic Purkinje cells that showed an altered structure of their...

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Identifiers

PMID: 23505473
DOI: 10.1371/journal.pone.0058259
PMCID: PMC3591433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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