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Article

Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin.

PloS one - 1 Jan 2014

Smith Karen Müller, Maragnoli Maria Elisabetta, Phull Pooja M, Tran Kathy May, Choubey Lisha, Vaccarino Flora M

Abstract excerpt

Fibroblast growth factors (Fgfs) and their receptors (Fgfr) are expressed in the developing and adult CNS. Previous studies demonstrated a decrease in cortical interneurons and locomotor hyperactivity in mice with a conditional Fgfr1 deletion generated in radial glial cells during midneurogenesis (Fgfr1(f/f);hGfapCre+). Here, we report earlier and more extensive inactivation of Fgfr1 in neuroepithelial cells of...

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Identifiers

PMID: 25116473
DOI: 10.1371/journal.pone.0103696
PMCID: PMC4130531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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