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Article

Systemic gene delivery to the central nervous system using Adeno-associated virus

2 Jun 2014

Abstract excerpt

Adeno-associated virus (AAV)-mediated gene delivery has emerged as an effective and safe tool for both preclinical and clinical studies of neurological disorders. The recent discovery that several serotypes are able to cross the blood-brain barrier when administered systemically has been a real breakthrough in the field of neurodegenerative diseases. Widespread transgene expression after systemic injection could...

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PMID: 24917785
DOI: 10.3389/fnmol.2014.00050

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