Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice.

BioMed research international - 1 Jan 2013

Iida Asako, Takino Naomi, Miyauchi Hitomi, Shimazaki Kuniko, Muramatsu Shin-ichi

Abstract excerpt

Recombinant adeno-associated virus (AAV) vectors are powerful tools for both basic neuroscience experiments and clinical gene therapies for neurological diseases. Intravascularly administered self-complementary AAV9 vectors can cross the blood-brain barrier. However, AAV9 vectors are of limited usefulness because they mainly transduce astrocytes in adult animal brains and have restrictions on foreign DNA package...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dependovirus
Share to Motor Neurons
Share to Neuroglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Purkinje Cells

Share to Spinal Cord

Share to Substantia Nigra

Share to Transduction, Genetic

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 23762870
DOI: 10.1155/2013/974819
PMCID: PMC3671507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice.PMID 23762870Read ↗

The advent of AAV9 expands applications for brain and spinal cord gene deliverySemantic proximity Read ↗

Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS VectorSemantic proximity Read ↗

Adeno-Associated Virus Vector for Central Nervous System Gene Therapy.Semantic proximity Read ↗

Adeno-Associated Virus (AAV) Vectors in the CNSSemantic proximity Read ↗

Systemic Gene Delivery in Large Species for Targeting Spinal Cord, Brain, and Peripheral Tissues for Pediatric DisordersSemantic proximity Read ↗

Biology of adeno-associated viral vectors in the central nervous systemSemantic proximity Read ↗

A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequencesSemantic proximity Read ↗

Routes of administration for adeno-associated viruses carrying gene therapies for brain diseasesSemantic proximity Read ↗

Adeno-Associated Virus (AAV) Vectors in the CNSSemantic proximity Read ↗

Advances in AAV-mediated gene replacement therapy for pediatric monogenic neurological disordersSemantic proximity Read ↗

Transduction of the Central Nervous System After Intracerebroventricular Injection of Adeno-Associated Viral Vectors in Neonatal and Juvenile MiceSemantic proximity Read ↗

Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.