Article
The effect of peptide deletions on the glycosylation of murine immunoglobulin M heavy chains.
Archives of biochemistry and biophysics - 1 Jun 1990
Finley E M, Rebbe N F, Hickman S
Abstract excerpt
The glycosylation and processing of the asparagine-linked oligosaccharides at individual glycosylation sites on the mu-chain of murine immunoglobulin M were investigated using variant cell lines that synthesize and secrete IgM heavy chains with known peptide deletions. Normal murine IgM has five...
Topics
- Animals
- Chromatography, Gel
- Glycopeptides
- Glycosylation
- Hybridomas
- Immunoglobulin M
- Mice
- Mutation
- Protein Processing, Post-Translational
- Structure-Activity Relationship