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Article

Assembly of IgM. Role of disulfide bonding and noncovalent interactions.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1995

Wiersma E J, Shulman M J

Abstract excerpt

Polymeric IgM is usually envisaged as an array of mu 2L2 monomers in which the mu heavy chains are held together by disulfide bonds involving cysteines at positions 337, 414, and 575. We have studied the importance of inter-mu-chain disulfide bonds for formation of IgM polymers and monomers by analyzing the effects of eliminating one or more of these disulfide bondings. Ablation of all inter-chain bonds by either...

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PMID: 7730630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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