Assembly of IgM. Role of disulfide bonding and noncovalent interactions.

Article

Assembly of IgM. Role of disulfide bonding and noncovalent interactions.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1995

Wiersma E J, Shulman M J

Abstract excerpt

Polymeric IgM is usually envisaged as an array of mu 2L2 monomers in which the mu heavy chains are held together by disulfide bonds involving cysteines at positions 337, 414, and 575. We have studied the importance of inter-mu-chain disulfide bonds for formation of IgM polymers and monomers by an...

Topics

Animals
Base Sequence
Blotting, Northern
Cell Line
Chromatography, High Pressure Liquid
Disulfides
Electrophoresis, Polyacrylamide Gel
Immunoglobulin G
Immunoglobulin M
Mice
Molecular Sequence Data
Mutation

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