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Article

Molecular Mechanism of Chemoresistance by Astrocyte Elevated Gene-1

13 Apr 2010

Abstract excerpt

Our recent findings show that astrocyte elevated gene-1 (AEG-1) is overexpressed in >90% of human hepatocellular carcinoma (HCC) samples, and AEG-1 plays a central role in regulating development and progression of HCC. In the present study, we elucidate a molecular mechanism of AEG-1-induced chemoresistance, an important characteristic of aggressive cancers. AEG-1 increases the expression of multidrug resistance...

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PMID: 20388796
DOI: 10.1158/0008-5472.can-09-4009

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