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Article

AEG-1 Regulates Retinoid X Receptor and Inhibits Retinoid Signaling

13 Aug 2014

Abstract excerpt

Retinoid X receptor (RXR) regulates key cellular responses such as cell growth and development, and this regulation is frequently perturbed in various malignancies, including hepatocellular carcinoma (HCC). However, the molecule(s) that physically govern this deregulation are mostly unknown. Here, we identified RXR as an interacting partner of astrocyte-elevated gene-1 (AEG-1)/metadherin (MTDH), an oncogene...

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PMID: 25125681
DOI: 10.1158/0008-5472.can-14-0421

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