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Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression

16 Feb 2009

Abstract excerpt

Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by diverse etiology, activation of multiple signal transduction pathways, and various gene mutations. Here, we have determined a specific role for astrocyte elevated gene-1 (AEG1) in HCC pathogenesis. Expression of AEG1 was extremely low in human hepatocytes, but its levels were significantly increased in human HCC. Stable...

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PMID: 19221438
DOI: 10.1172/jci36460

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