Article
Learning a peptide-protein binding affinity predictor with kernel ridge regression.
BMC bioinformatics - 5 Mar 2013
Giguère Sébastien, Marchand Mario, Laviolette François, Drouin Alexandre, Corbeil Jacques
Abstract excerpt
BACKGROUND: The cellular function of a vast majority of proteins is performed through physical interactions with other biomolecules, which, most of the time, are other proteins. Peptides represent templates of choice for mimicking a secondary structure in order to modulate protein-protein interaction. They are thus an interesting class of therapeutics since they also display strong activity, high selectivity, low...
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