Continued development of an empirical function for predicting and rationalizing protein-protein binding affinities.

Abstract excerpt

Here we summarize recent work on the continued development of our fast and simple empirical equation for predicting and structurally rationalizing protein-protein and protein-peptide binding affinities. Our empirical expression consists of six regression-weighted physical descriptors and derives from two key simplifying assumptions: (1) the assumption of rigid-body association and (2) the assumption that all...

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