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Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice

22 Feb 2010

Abstract excerpt

BACKGROUND: Apert syndrome is characterized by craniosynostosis and limb abnormalities and is primarily caused by FGFR2 +/P253R and +/S252W mutations. The former mutation is present in approximately one third whereas the latter mutation is present in two-thirds of the patients with this condition. We previously reported an inbred transgenic mouse model with the Fgfr2 +/S252W mutation on the C57BL/6J background...

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PMID: 20175913
DOI: 10.1186/1471-213x-10-22

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