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Article

FGF/FGFR signaling coordinates skull development by modulating magnitude of morphological integration: evidence from Apert syndrome mouse models.

PloS one - 1 Jan 2011

Martínez-Abadías Neus, Heuzé Yann, Wang Yingli, Jabs Ethylin Wang, Aldridge Kristina, Richtsmeier Joan T

Abstract excerpt

The fibroblast growth factor and receptor system (FGF/FGFR) mediates cell communication and pattern formation in many tissue types (e.g., osseous, nervous, vascular). In those craniosynostosis syndromes caused by FGFR1-3 mutations, alteration of signaling in the FGF/FGFR system leads to dysmorphology of the skull, brain and limbs, among other organs. Since this molecular pathway is widely expressed throughout...

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Identifiers

PMID: 22053191
DOI: 10.1371/journal.pone.0026425
PMCID: PMC3203899

Genes

FGFR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FGF/FGFR signaling coordinates skull development by modulating magnitude of morphological integration: evidence from Apert syndrome mouse models.PMID 22053191Read ↗

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