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Article

Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse.

Development (Cambridge, England) - 1 Aug 2005

Wang Yingli, Xiao Ran, Yang Fan, Karim Baktiar O, Iacovelli Anthony J, Cai Juanliang, Lerner Charles P, Richtsmeier Joan T, Leszl Jen M, Hill Cheryl A, Yu Kai, Ornitz David M, Elisseeff Jennifer, Huso David L, Jabs Ethylin Wang

Abstract excerpt

Apert syndrome is an autosomal dominant disorder characterized by malformations of the skull, limbs and viscera. Two-thirds of affected individuals have a S252W mutation in fibroblast growth factor receptor 2 (FGFR2). To study the pathogenesis of this condition, we generated a knock-in mouse model with this mutation. The Fgfr2(+/S252W) mutant mice have abnormalities of the skeleton, as well as of other organs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15975938
DOI: 10.1242/dev.01914

Genes

FGFR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse.PMID 15975938Read ↗

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