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Article

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome.

EMBO molecular medicine - 1 Mar 2013

Pinheiro Iris, Dejager Lien, Petta Ioanna, Vandevyver Sofie, Puimège Leen, Mahieu Tina, Ballegeer Marlies, Van Hauwermeiren Filip, Riccardi Carlo, Vuylsteke Marnik, Libert Claude

Abstract excerpt

Natural variation for LPS-induced lethal inflammation in mice is useful for identifying new genes that regulate sepsis, which could form the basis for novel therapies for systemic inflammation in humans. Here we report that LPS resistance of the inbred mouse strain SPRET/Ei, previously reported to depend on the glucocorticoid receptor (GR), maps to the distal region of the X-chromosome. The GR-inducible gene...

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PMID: 23495141
DOI: 10.1002/emmm.201201683
PMCID: PMC3598084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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