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Article

Oestrogen sulfotransferase ablation sensitizes mice to sepsis.

Nature communications - 10 Aug 2015

Chai Xiaojuan, Guo Yan, Jiang Mengxi, Hu Bingfang, Li Zhigang, Fan Jie, Deng Meihong, Billiar Timothy R, Kucera Heidi R, Gaikwad Nilesh W, Xu Meishu, Lu Peipei, Yan Jiong, Fu Haiyan, Liu Youhua, Yu Lushan, Huang Min, Zeng Su, Xie Wen

Abstract excerpt

Sepsis is the host's deleterious systemic inflammatory response to microbial infections. Here we report an essential role for the oestrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response. Both the caecal ligation and puncture (CLP) and lipopolysaccharide models of sepsis induce the expression of EST and compromise the activity of oestrogen, an...

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PMID: 26259151
DOI: 10.1038/ncomms8979
PMCID: PMC4532951

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