Glucocorticoid-induced leucine zipper "quantifies" stressors and increases male susceptibility to PTSD.

doi:10.1038/s41398-019-0509-3

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Article

Glucocorticoid-induced leucine zipper "quantifies" stressors and increases male susceptibility to PTSD.

Translational psychiatry - 25 Jul 2019

Lebow Maya A, Schroeder Mariana, Tsoory Michael, Holzman-Karniel Dorin, Mehta Divya, Ben-Dor Shifra, Gil Shosh, Bradley Bekh, Smith Alicia K, Jovanovic Tanja, Ressler Kerry J, Binder Elisabeth B, Chen Alon

Abstract excerpt

Post-traumatic stress disorder (PTSD) selectively develops in some individuals exposed to a traumatic event. Genetic and epigenetic changes in glucocorticoid pathway sensitivity may be essential for understanding individual susceptibility to PTSD. This study focuses on PTSD markers in the glucocorticoid pathway, spotlighting glucocorticoid-induced leucine zipper (GILZ), a transcription factor encoded by the gene...

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Topics

Adult
Amygdala
Animals
Behavior, Animal
Cohort Studies
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Disease Models, Animal

Disease Susceptibility

Epigenesis, Genetic

Female

Genetic Predisposition to Disease

Glucocorticoids

Humans

Male

Mice

Mice, Inbred ICR

Microarray Analysis

Pregnancy

Source

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Identifiers

PMID: 31346158
DOI: 10.1038/s41398-019-0509-3
PMCID: PMC6658561

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