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Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2018

Timmermans Steven, Souffriau Jolien, Vandewalle Jolien, Van Wyngene Lise, Van Looveren Kelly, Vanderhaeghen Tineke, Libert Claude

Abstract excerpt

Inbred mouse strains derived from the species Mus spretus have been very informative in the study of certain gene polymorphisms in inflammation and infection. Based on our interest in sepsis, we used SPRET/EiJ mice and mapped several critical loci that are linked to sensitivity to cytokine-induced inflammation and endotoxemia. These studies were based on prominent phenotypes that have never been observed in...

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PMID: 29947962
DOI: 10.1007/s00335-018-9751-x

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