Article
Identification of novel genes that mediate innate immunity using inbred mice.
Genetics - 1 Dec 2009
Yang Ivana V, Wade Claire M, Kang Hyun Min, Alper Scott, Rutledge Holly, Lackford Brad, Eskin Eleazar, Daly Mark J, Schwartz David A
Abstract excerpt
Innate immunity is the first line of defense against microbial infections. Although polymorphisms in toll-like receptors (TLRs) and downstream signaling molecules (CD14, TLR2, TLR4, TLR5, and IRAK4) affect the innate immune response, these variants account for only a portion of the ability of the host to respond to bacteria, fungi, and viruses. To identify other genes involved in the innate immune response, we...
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