Article
Quantitative trait loci modulate neutrophil infiltration in the liver during LPS-induced inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2000
Matesic L E, Niemitz E L, De Maio A, Reeves R H
Abstract excerpt
A crucial aspect of the inflammatory response is the recruitment of activated neutrophils (PMN) to the site of damage. Lytic enzymes and oxygen radicals released by PMN are important in clearing an infection or cellular debris, but can also produce host tissue damage. Failure to properly regulate the inflammatory response contributes to a variety of human diseases like sepsis and multiple organ dysfunction...
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