Article
Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2004
Staelens Jan, Puimège Leen, Mahieu Tina, Pynaert Gwenda, Hochepied Tino, Vandenabeele Annelies, Grooten Johan, Kontoyiannis Dimitris, Van Roy Frans, Kollias George, Libert Claude
Abstract excerpt
Most inflammatory disorders are becoming more prevalent, especially in Western countries. The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) plays a prominent role in many of these inflammatory disorders. We have previously shown that SPRET/Ei mice exhibit an extreme and dominant resistance to high doses of TNF. In this report, we investigate the response of heterozygous (C57BL/6xSPRET/Ei)F1 mice in...
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