Article

Factor H related 2 levels dictate FHR dimer composition

2025-03-10

Abstract excerpt

<title>Abstract</title> <p>Factor H-related (FHR) protein 1 and 2 form dimers resulting in FHR-1 and -2 homodimers, and FHR-1/2 heterodimers. Dimerization is hypothesized to further increase their antagonistic function with complement regulator factor H (FH). So far, only FHR-1 homodimers and FHR-1/2 heterodimers could be quantified in a direct way. With the reported genetic associations between CFHR2 and complem...

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Literature Corpus work: 2d98489f-2dc3-532e-9be0-08c3b8107a32
DOI: 10.21203/rs.3.rs-6130401/v1

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