[Advances in research for relationship between mitochondrial DNA and solid tumor].

Abstract excerpt

Mitochondrial DNA (mtDNA) encodes the polypeptides required for oxidative phosphorylation and genesis of ATP. It has been though to be involved in carcinogenesis because of its high mutation rate and lacking effective repair mechanism in contrast to nuclear DNA. Since mtDNA lacks introns, it has been suggested that most mutations will occur in this coding sequence and subsequent accumulation of mutation may lead...

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