Article
An unholy alliance: cooperation between BRAF and NF1 in melanoma development and BRAF inhibitor resistance.
Cancer discovery - 1 Mar 2013
Gibney Geoffrey T, Smalley Keiran S M
Abstract excerpt
In this issue of Cancer Discovery, 2 studies provide new evidence implicating loss of the tumor suppressor neurofibromin (NF1) in the biologic behavior of cutaneous melanoma. The first study from Maertens and colleagues describes a new transgenic mouse model in which mutant BRAF cooperates with NF1 loss to drive melanoma development through the abrogation of oncogene-induced senescence. The second, from Whittaker...
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