Article
Multiple roles of NF1 in the melanocyte lineage.
Pigment cell & melanoma research - 1 Jul 2016
Larribère Lionel, Utikal Jochen
Abstract excerpt
NF1 is a tumour suppressor gene, germline mutations of which lead to neurofibromatosis type 1 syndrome. Patients develop benign tumours from several types of cells including neural crest-derived cells. NF1 somatic mutations also occur in 15% of sporadic melanoma, a cancer originating from melanocytes. Evidence now suggests the involvement of NF1 mutations in melanoma resistance to targeted therapies. Although NF1...
Topics
- Animals
- Cell Lineage
- Humans
- Melanocytes
- Melanoma
- Mutation
- Neurofibromin 1
- Skin Neoplasms
- Melanoma, Cutaneous Malignant