Article
Genetic profile of naïve untreated primary cutaneous melanomas with a negative sentinel lymph node.
Clinical and experimental dermatology - 1 Dec 2020
Yang K, Oh K S, Mahalingam M
Abstract excerpt
Sentinel lymph node (SLN) biopsy is typically offered to patients with primary cutaneous melanomas (PCMs) of ≥ 1 mm depth, but not all SLNs are positive using this cutoff. To ascertain whether positivity is genetically regulated, genetic analysis was performed using an augmented enrichment-based next-generation DNA and RNA sequencing assay in SLN-negative (Group 1, n = 8, mean depth 1.3 mm) and SLN-positive PCMs...
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