Article

Loss of neurofibromin accelerates uveal and dermal melanoma formation driven by GNAQ

2024-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Neurofibromin is a very large and complex tumor suppressor, whose loss can synergize with other MAPK pathway mutations to promote melanoma in the skin. In this paper, we investigated whether NF1 loss has a role in other melanomas, such as those that form in the dermis or eye (uveal tract). We found that heterozygous 17q11.2 loss that includes the NF1 locus is an uncommon, but recurrent phenome...

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Literature Corpus work: f92da45b-14db-5c3e-8f5f-6c616b176e3b
DOI: 10.1101/2024.06.26.600903

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