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Article

Pathophysiology of anthracycline cardiotoxicity.

Journal of cardiovascular medicine (Hagerstown, Md.) - 1 May 2016

Mele Donato, Tocchetti Carlo G, Pagliaro Pasquale, Madonna Rosalinda, Novo Giuseppina, Pepe Alessia, Zito Concetta, Maurea Nicola, Spallarossa Paolo

Abstract excerpt

Anthracyclines (ANTs) are powerful drugs that have reduced the mortality of cancer patients. However, their use is limited by the development of cardiotoxicity (CTX), which is dose dependent and may lead to left ventricular dysfunction and heart failure. Although various strategies have been suggested to reduce the negative effects of ANTs, CTX is still an important unresolved clinical issue. This may be due at...

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Source

Identifiers

PMID: 27183523
DOI: 10.2459/JCM.0000000000000378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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