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Article

Chronic NOS inhibition prevents adverse lung remodeling and pulmonary arterial hypertension in caveolin-1 knockout mice.

Pulmonary pharmacology & therapeutics - 1 Jan 2008

Wunderlich Carsten, Schmeisser Alexander, Heerwagen Christian, Ebner Bernd, Schober Kristin, Braun-Dullaeus Ruediger C, Schwencke Carsten, Kasper Michael, Morawietz Henning, Strasser Ruth H

Abstract excerpt

Recently generated caveolin-1 deficient mice (cav-1 ko) suffer from severe lung fibrosis with marked pulmonary hypertension and arterial hypoxemia and may therefore serve as an useful animal model of this devastating human disorder. Accumulating evidence strongly supports the negative regulatory influence of caveolin-1 on endothelial nitric oxide synthase resulting in a constitutive hyperactivation of the nitric...

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Source

Identifiers

PMID: 18226570
DOI: 10.1016/j.pupt.2007.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chronic NOS inhibition prevents adverse lung remodeling and pulmonary arterial hypertension in caveolin-1 knockout mice.PMID 18226570Read ↗

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