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Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignment

23 Feb 2011

Abstract excerpt

BACKGROUND: Chromosome segregation errors during human oocyte meiosis are associated with low fertility in humans and the incidence of these errors increases with advancing maternal age. Studies of mitosis and meiosis suggest that defective remodeling of chromatin plays a causative role in aneuploidy. We analyzed the histone deacetylation pattern during the final stages of human oocyte maturation to investigate...

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PMID: 21349858
DOI: 10.1093/humrep/der030

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