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Article

Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice

1 May 2006

Abstract excerpt

Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions and birth defects. Almost all such aneuploidy derives from meiotic errors in females, with increasing maternal age representing a major risk factor. It was recently reported that histones are globally deacetylated in mammalian oocytes during meiosis but not mitosis. In the present study, inhibition of meiotic histone...

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PMID: 16651529
DOI: 10.1073/pnas.0510946103

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