Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Vivo Application of Histone Deacetylase Inhibitor Trichostatin‐A Impairs Murine Male Meiosis

28 Feb 2008

Abstract excerpt

In vivo application of histone deacetylase (HDAC) inhibitor trichostatin-A (TSA) in mice results in male infertility. To get more insight into the mechanisms underlying this phenomenon, we performed a genome-wide expression analysis and investigated HDAC activity and degree of histone H3 and H4 acetylation in murine testes after TSA treatment. A significant decrease in HDAC activity and a weak increase in histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18046049
DOI: 10.2164/jandrol.107.003848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Vivo Application of Histone Deacetylase Inhibitor Trichostatin‐A Impairs Murine Male MeiosisPMID 18046049Read ↗

Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytes.Semantic proximity Read ↗

The Effects of Trichostatin A on mRNA Expression of Chromatin Structure-, DNA Methylation-, and Development-Related Genes in Cloned Mouse BlastocystsSemantic proximity Read ↗

Histone acetylation regulated by histone deacetylases during spermatogenesisSemantic proximity Read ↗

Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryosSemantic proximity Read ↗

MC1568 Enhances Histone Acetylation During Oocyte Meiosis and Improves Development of Somatic Cell Nuclear Transfer Embryos in PigSemantic proximity Read ↗

Trichostatin A Promotes the Development of Bovine Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errorsSemantic proximity Read ↗

Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transferSemantic proximity Read ↗

Changes in histone acetylation during mouse oocyte meiosisSemantic proximity Read ↗

Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonadsSemantic proximity Read ↗

Trichostatin A Improves Histone Acetylation in Bovine Somatic Cell Nuclear Transfer Early EmbryosSemantic proximity Read ↗

Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.