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Article

Large-scale functional purification of recombinant HIV-1 capsid.

PloS one - 1 Jan 2013

Hung Magdeleine, Niedziela-Majka Anita, Jin Debi, Wong Melanie, Leavitt Stephanie, Brendza Katherine M, Liu Xiaohong, Sakowicz Roman

Abstract excerpt

During human immunodeficiency virus type-1 (HIV-1) virion maturation, capsid proteins undergo a major rearrangement to form a conical core that protects the viral nucleoprotein complexes. Mutations in the capsid sequence that alter the stability of the capsid core are deleterious to viral infectivity and replication. Recently, capsid assembly has become an attractive target for the development of a new generation...

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Identifiers

PMID: 23472130
DOI: 10.1371/journal.pone.0058035
PMCID: PMC3589475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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