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Article

Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499

3 Sept 2025

Abstract excerpt

ABSTRACT With its high degree of conservation and critical role in multiple steps of the HIV-1 life cycle, the HIV-1 capsid protein presents an attractive therapeutic target. Herein, the virologic properties of the HIV-1 capsid inhibitors VH4004280 (VH-280) and VH4011499 (VH-499), including potency, mechanisms of action, and resistance profiles, are described. VH-280 and VH-499 inhibited panels of HIV-1...

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Identifiers

PMID: 40899688
DOI: 10.1128/aac.00309-25

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