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Article

A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation.

Disease models & mechanisms - 1 May 2013

Ahmed Jehangir N, Ali Radiya G, Warr Nicholas, Wilson Heather M, Bellchambers Helen M, Barratt Kristen S, Thompson Amelia J, Arkell Ruth M

Abstract excerpt

The ZIC transcription factors are key mediators of embryonic development and ZIC3 is the gene most commonly associated with situs defects (heterotaxy) in humans. Half of patient ZIC3 mutations introduce a premature termination codon (PTC). In vivo, PTC-containing transcripts might be targeted for nonsense-mediated decay (NMD). NMD efficiency is known to vary greatly between transcripts, tissues and individuals...

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Source

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Identifiers

PMID: 23471918
DOI: 10.1242/dmm.011668
PMCID: PMC3634658

Genes

ZIC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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