Article
Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain.
Human molecular genetics - 15 Nov 2008
Hatayama Minoru, Tomizawa Tadashi, Sakai-Kato Kumiko, Bouvagnet Patrice, Kose Shingo, Imamoto Naoko, Yokoyama Shigeyuki, Utsunomiya-Tate Naoko, Mikoshiba Katsuhiko, Kigawa Takanori, Aruga Jun
Abstract excerpt
Disruptions in ZIC3 cause heterotaxy, a congenital anomaly of the left-right axis. ZIC3 encodes a nuclear protein with a zinc finger (ZF) domain that contains five tandem C2H2 ZF motifs. Missense mutations in the first ZF motif (ZF1) result in defective nuclear localization, which may underlie the pathogenesis of heterotaxy. Here we revealed the structural and functional basis of the nuclear localization signal...
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