Identification of a novel role of ZIC3 in regulating cardiac development.

doi:10.1093/hmg/ddm106

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Article

Identification of a novel role of ZIC3 in regulating cardiac development.

Human molecular genetics - 15 Jul 2007

Zhu Lirong, Harutyunyan Karine G, Peng Jian Lan, Wang Jun, Schwartz Robert J, Belmont John W

Abstract excerpt

Mutations in ZIC3 cause X-linked heterotaxy, a disorder characterized by abnormal lateralization of normally asymmetric thoracic and abdominal organs. Animal models demonstrate an early role for ZIC3 in embryonic left-right (LR) patterning. ZIC3 mutations have also been described in patients with isolated cardiovascular malformations. We wished to address the hypothesis that ZIC3 has plieotropic effects in...

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Identifiers

PMID: 17468179
DOI: 10.1093/hmg/ddm106

Genes

ZIC3
SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.