Article
Further characterization of the genetic defect of the Bent tail mouse, a mouse model for human neural tube defects.
Birth defects research. Part A, Clinical and molecular teratology - 1 Nov 2004
Klootwijk Riko, Schijvenaars Mascha M V A P, Mariman Edwin C M, Franke Barbara
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) are congenital malformations arising mostly from incomplete neural tube closure during early embryogenesis. Most NTDs in humans have a complex etiology, with involvement of both genetic and environmental factors. More than 100 mouse models for human neural tube defects exist; Bent tail is one of them. The mouse mutant is caused by a submicroscopic deletion on Xq that...
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