Article
Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice.
Human molecular genetics - 1 Jun 2001
Ikeda A, Ikeda S, Gridley T, Nishina P M, Naggert J K
Abstract excerpt
The tubby-like protein 3 (Tulp3) gene has been identified as a member of a small novel gene family which is primarily neuronally expressed. Mutations in two of the family members, tub and tulp1, have been shown to cause neurosensory disorders. To determine the in vivo function of Tulp3, we have generated a germline mutation in the mouse Tulp3 gene by homologous recombination. Embryos homozygous for the Tulp3...
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