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Article

Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease.

PloS one - 1 Jan 2011

Bedard James E J, Haaning Allison M, Ware Stephanie M

Abstract excerpt

Patients with heterotaxy have characteristic cardiovascular malformations, abnormal arrangement of their visceral organs, and midline patterning defects that result from abnormal left-right patterning during embryogenesis. Loss of function of the transcription factor ZIC3 causes X-linked heterotaxy and isolated congenital heart malformations and represents one of the few known monogenic causes of congenital heart...

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Identifiers

PMID: 21858219
DOI: 10.1371/journal.pone.0023755
PMCID: PMC3157443

Genes

ZIC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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