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Article

Role of prostaglandins in fibroblast activation and fibrosis

25 Mar 2010

Abstract excerpt

Fibroblasts release prostaglandins and express a range of prostanoid receptors. However the importance of prostaglandins in fibroblast biology have not been fully explored. Our studies showed that the prostaglandin metabolite PGI(2) blocks the activation of fibroblasts, antagonising the induction of Ras/MEK/ERK signalling by TGFbeta. Endogenous PGI(2) acts so as to limit the activation of fibroblasts following...

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PMID: 20531982
DOI: 10.1007/s12079-010-0089-8

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