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Dysplastic Epithelial Repair Propagates Chronic Pathology Through the Paracrine Transformation of Pulmonary Fibroblasts

2026-04-05

Abstract excerpt

Severe lung injury promotes the ectopic accumulation of basal cells in the alveoli and the presence of these dysplastic epithelial cells are strongly associated with regions of pulmonary fibrosis (PF) in diseased lungs. Recent studies have identified a unique subset of “inflammatory” fibroblasts expressing pro-inflammatory genes, especially cytokines involved in monocyte recruitment, that are also enriched in dise...

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Literature Corpus work
8e50e3a9-1b13-55ea-8184-4c4d35bd7463
DOI
10.64898/2026.04.02.716135
Open publication

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