Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.

Carcinogenesis - 1 Dec 2007

Pandey Jyotsna, Umphress Sarah M, Kang Yang, Angdisen Jerry, Naumova Alena, Mercer Kim L, Jacks Tyler, Jakowlew Sonia B

Abstract excerpt

Oncogenic K-ras is one of the most common genetic alterations in human lung adenocarcinomas. In addition, inactivation of clusters of tumor suppressor genes is required to bring about classical characteristics of cancer including angiogenesis as a prelude to invasion and metastasis. Transforming growth factor-beta (TGF-beta) 1 is a tumor suppressor gene that is implicated in lung cancer progression. Although in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Disease Progression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to Lung Neoplasms

Share to Mice, Mutant Strains

Share to Neovascularization, Pathologic

Share to Oligonucleotide Array Sequence Analysis

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 17690114
DOI: 10.1093/carcin/bgm136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.PMID 17690114Read ↗

Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma.Semantic proximity Read ↗

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growthSemantic proximity Read ↗

TGFΒ-induced transcription in cancerSemantic proximity Read ↗

Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells.Semantic proximity Read ↗

Role of transforming growth factor-beta in cancer progression.Semantic proximity Read ↗

Molecular Mechanisms of Hepatocarcinogenesis in Transgenic Mouse Models of Liver CancerSemantic proximity Read ↗

Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas.Semantic proximity Read ↗

An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo.Semantic proximity Read ↗

Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis.Semantic proximity Read ↗

Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.Semantic proximity Read ↗

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progressionSemantic proximity Read ↗

LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.