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Article

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization

1 Jul 2021

Abstract excerpt

Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor prognosis. In this study, we use isogenic cancer cell lines to identify SMAD4 regulated genes that contribute to the development of metastatic colonization. We perform an in...

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PMID: 34320363
DOI: 10.1016/j.celrep.2021.109443

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