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Article

Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans.

Human molecular genetics - 1 Jan 2005

Zheng Qing Yin, Yan Denise, Ouyang Xiao Mei, Du Li Lin, Yu Heping, Chang Bo, Johnson Kenneth R, Liu Xue Zhong

Abstract excerpt

Mutations in genes coding for cadherin 23 and protocadherin 15 cause deafness in both mice and humans. Here, we provide evidence that mutations at these two cadherin loci can interact to cause hearing loss in digenic heterozygotes of both species. Using a classical genetic approach, we generated mice that were heterozygous for both Cdh23 and Pcdh15 mutations on a uniform C57BL/6J background. Significant levels of...

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Source

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Identifiers

PMID: 15537665
DOI: 10.1093/hmg/ddi010
PMCID: PMC2858222

Genes

CDH23
PCDH15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans.PMID 15537665Read ↗

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