Article
Association between mismatch repair gene MSH3 codons 1036 and 222 polymorphisms and sporadic prostate cancer in the Iranian population.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012
Jafary Fariba, Salehi Mansoor, Sedghi Maryam, Nouri Nayereh, Jafary Farzaneh, Sadeghi Farzaneh, Motamedi Shima, Talebi Maede
Abstract excerpt
The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls and 18 patients were...
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